The Million Veteran Program (MVP) is a research program from the U.S. Department of Veterans Affairs (VA) that has collected and analyzed health information from over one million veteran volunteers. The data include genes, lifestyles, military experiences, and exposures that may impact health and wellness.   The results of the MVP phenome-wide association study (PheWAS) … Continue reading Open Access! Million Veteran Program Genome-Wide PheWAS Results Now Available in dbGaP! →

22 July 2024

Effective August 2024, core_nt will become the default  Interested in faster nucleotide BLAST searches with more focused search results? As previously announced, NCBI has been re-evaluating the BLAST nucleotide database (nt) to make it more compact and more efficient. Thanks to your feedback, NCBI’s BLAST is excited to introduce the core nucleotide database (core_nt), an … Continue reading Get Faster, More Focused Search Results with NCBI’s New BLAST Core Nucleotide Database (core_nt) →

18 July 2024

Do you rely on high-quality and up-to-date genetic test information from the NIH Genetic Testing Registry (GTR)? Laboratories are expected to regularly review their tests, lab contacts, and license data for accuracy. GTR is making the annual review process for submitters easier and more intuitive to ensure we provide you the most current information.  Attention … Continue reading NIH Genetic Testing Registry (GTR®) Annual Review Process Ensures High-Quality Data →

16 July 2024

Check out RefSeq release 225, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. What’s included in this release? As of July 8, 2024, this full release incorporates genomic, transcript, and protein data containing: 448,507,905 records 334,845,613 proteins 63,542,774 RNAs Sequences from 152,668 organisms The release is provided in several directories as … Continue reading RefSeq Release 225 Now Available! →

15 July 2024

The Immunoglobulin (Ig) fold is the most common protein structure unit in the human proteome and is involved in many cellular signaling pathways. NCBI along with researchers at the National Cancer Institute and California State University, Northridge have developed a universal reference numbering scheme for Ig folds, now available in the iCn3D structure viewer, to … Continue reading Universal Reference Numbers for Ig Domains Now Available in NCBI’s iCn3D Structure Viewer →

10 July 2024

Did you know NCBI’s PubChem is the world’s largest collection of freely accessible chemical information? You can search chemicals by name, molecular formula, structure, and other identifiers, as well as find chemical and physical properties, biological activities, safety and toxicity information, patents, literature citations and more. We are constantly adding new data and working on … Continue reading Quickly Find Chemical Information with PubChem →

3 July 2024

Classic website no longer available effective June 25, 2024  We appreciate all the feedback received since the launch of the modernized ClinicalTrials.gov website in June 2023, and we’ve incorporated many of your suggestions. As announced last month, the classic website has remained available to help you transition to the modernized website. Effective today, the classic … Continue reading A Modern ClinicalTrials.gov Website →

25 June 2024

GenBank release 261.0 (6/18/2024) is now available on the NCBI FTP site. This release has 32.04 trillion bases and 4.51 billion records.  The current release has: 251,094,334 traditional records containing 3,387,240,663,231 base pairs of sequence data 3,380,877,515 WGS records containing 27,900,199,328.,333 base pairs of sequence data 746,753,803 bulk-oriented TSA records containing 695,405,769,319 base pairs of … Continue reading GenBank Release 261.0 is Available! →

20 June 2024

NCBI is continually making improvements to our Taxonomy resource in response to new data and changes in biological nomenclature and classification. In the coming months, we will update the higher-level classification of birds (Aves), budding yeasts (Saccharomycotina), prokaryotes (Bacteria and Archaea) and Viruses. This update will also change the formal ranks of several high-level taxonomic … Continue reading Upcoming Changes to NCBI Taxonomy Classifications →

4 June 2024

Access to comprehensive and accurate allele frequency data is essential to understanding the impact of genetic variations on human health and disease. Allele Frequency Aggregator (ALFA) provides the Database of Single Nucleotide Polymorphisms (dbSNP) with allele frequency data for 200K subjects from the Database of Genotypes and Phenotypes (dbGaP). ALFA adheres to the Findable, Accessible, … Continue reading Explore Population Genetics in dbSNP with NCBI’s Allele Frequency Aggregator (ALFA) →

30 May 2024