New tutorials, queries, and discovery guides now available  NLM’s NCBI Bookshelf provides free access to more than 13,000 peer-reviewed books and documents in life science and health care using over a dozen formats including monographs, reviews, reference works, government publications, standards and guidelines, technical reports, and textbooks. In acknowledgement of Open Access Week, we are … Continue reading Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips →

22 October 2024

The next step in the modernization of PMC  As previously announced, NLM’s NCBI transitioned to an updated PubMed Central (PMC) website, representing the next step in ongoing efforts to modernize NLM’s products and services. As part of this update, the primary URL for the PMC website has changed from ncbi.nlm.nih.gov/pmc to pmc.ncbi.nlm.nih.gov. In addition, you’ll … Continue reading PubMed Central (PMC) Transitions to Updated Website →

21 October 2024

Are you interested in comparing gene families or exploring the evolution of domain architecture? Try our Conserved Domain Architecture Retrieval Tool (CDART) to retrieve sets of proteins that share the same or similar domain superfamily architecture with your query. We recently updated CDART so it’s faster and more streamlined with simplified navigation and result filtering.  … Continue reading CDART: Find Proteins with Similar Domain Architecture →

17 October 2024

Important note! The storage tier for Sequence Read Archive (SRA) data available through Amazon Web Services (AWS) commercial buckets is transitioning to Glacier Instant retrieval and Google Cloud Platform (GCP) is transitioning to Coldline. This change is projected to be complete by the end of October 2024. To mitigate the cost impact of this change, we recommend adjusting your … Continue reading Changes to SRA Data Access on Amazon Web Services (AWS) and Google Cloud Platform (GCP) →

16 October 2024

With support from the National Institute of Allergy and Infectious Diseases (NIAID)’s Office of Genomics and Advanced Technologies and the NCBI Pathogen Detection Project Team, NCBI hosted a successful virtual event, Resistance is Futile: A codeathon to combat antimicrobial resistance. This codeathon took place September 23-27, 2024, and brought together experts in the field of … Continue reading Successful NCBI-NIAID Codeathon Collaborating on Antimicrobial Resistance Data Analysis Projects →

10 October 2024

Increased flexibility, efficiency, and reliability  Do you use the NCBI Datasets command-line tools or API? As of January 2025, you will have the option to use an API key to increase your rate of access. This update will provide you more flexibility and efficiency, while still maintaining robust access for everyone. Note that these changes … Continue reading New API Key System Coming Soon to NCBI Datasets →

8 October 2024

As previously announced, NCBI is continuing to improve our Taxonomy resource. The International Code of Nomenclature of Prokaryotes (ICNP) recently introduced changes to the code of nomenclature that governs naming of prokaryotes. Following these changes, we are updating the higher-level classification of prokaryotes with the introduction of rank ‘kingdom’ and other changes for this group. The changes … Continue reading NCBI Taxonomy Updates to Prokaryotes →

2 October 2024

Are you interested in viewing how a protein interacts with a ligand? iCn3D, our 3D molecular structure viewer, now offers improved displays of these interactions at an atomic level.   Check out this example:  You are now able to see the interactions of an embedded ligand (such as the drug Gleevec in the protein ABL2) within … Continue reading Viewing Ligand-Protein Interactions in iCn3D →

30 September 2024

NCBI is streamlining the terminology around our reference genomes. We currently have a small set of genomes collectively called representatives and an even smaller set called references. We have slowly converged on the term reference to refer to both sets.   A genome is labeled reference if it is deemed to be the best available genome … Continue reading Updated Genomes Terminology! “Representative Genome” is Replaced with “Reference Genome” →

25 September 2024

Do you use genomes from NCBI and are concerned they may contain contaminant sequences? Now you can view reports generated for all prokaryotic and eukaryotic genomes with NCBI’s quality assurance tool, Foreign Contamination Screen (FCS), to better understand possible issues that may affect your studies.   What reports are available?  Summary reports to select better assemblies … Continue reading Access Public Reports of Foreign Contamination Screen (FCS) Tool Results →

24 September 2024