NCBI’s new Multiple Comparative Genome Viewer (MCGV) is an interactive graphical genome browser that allows you to visualize multiple genome assemblies in a single view. MCGV displays whole genome alignments created by the research community.  What’s new? We made several significant updates to this application since its initial release last winter! Now you can:   View … Continue reading Compare Nucleotide Differences in the Multiple Comparative Genome Viewer (MCGV)! →

18 June 2025

We are excited to announce an improved search and navigation experience in the NIH Genetic Testing Registry (GTR®) so you can find the tests you need in a more intuitive and powerful way. Try searching GTR on our new Beta site and let us know how we can improve!   What’s new?  1. One search box for … Continue reading Genetic Testing Registry (GTR®) Search Improvements →

12 June 2025

GenBank release 266.0 (4/25/2025) is now available on the NCBI FTP site. This release has 44.02 trillion bases and 5.68 billion records. The current release has:  257,038,531 traditional records containing 5,794,509,308,815 base pairs of sequence data 4,234,652,334 WGS records containing 37,294,058,110,495 base pairs of sequence data 996,759,705 bulk-oriented TSA records containing 852,869,986,922 base pairs of … Continue reading GenBank Release 266.0 Now Available! →

10 June 2025

Doubled cohort size to 409K We are thrilled to announce the NCBI Allele Frequency Aggregator (ALFA) Release 4 (R4), a leap forward in providing comprehensive and robust allele frequency information to the global scientific community. ALFA R4 doubles the cohort size from R3! This expansion offers greater resolution for variant frequencies across diverse populations, improving … Continue reading NCBI ALFA Release 4 Now Available →

9 June 2025

NCBI is excited to introduce a fresh look and feel to the Database of Genotypes and Phenotypes (dbGaP). Our beta homepage is now available and will become the default later in 2025. We encourage you to try it out and let us know what you think! This represents the first step of our ongoing modernization … Continue reading Beta Now Live! New & Improved dbGaP Homepage Design →

2 June 2025

Download the updated bacterial and archaeal reference Genome collection! We built this collection of 21,794 genomes by selecting the “best” genome assembly for each species among the 400,000+ prokaryotic genomes in RefSeq, which is 536 more than was included in the January release. What’s new? As previously announced, we now have an incremental release process. You … Continue reading Now Available: Updated Bacterial and Archaeal Reference Genome Collection →

27 May 2025

Effective August 2025, ClusteredNR will become the protein BLAST default database  We are excited to announce that the default database for protein BLAST searches will soon be the NCBI ClusteredNR database! Introduced in 2022, ClusteredNR is a collection of protein sequence clusters built from the current default database, nr. The representative sequence for each cluster … Continue reading Faster, Better Results for Protein BLAST Searches →

22 May 2025

Starting April 28, 2025 In December 2024, we announced several key changes to virus classification in the NCBI Taxonomy database. These updates are part of our ongoing efforts to ensure viral taxonomy reflects the latest scientific understanding and aligns with international standards set by the International Committee on Taxonomy of Viruses (ICTV). We will begin … Continue reading NCBI Taxonomy Updates to Virus Classification →

25 April 2025

As previously announced, NLM’s NCBI is modernizing the PubMed Central (PMC) website. The next step is to update the PMC search functionality and user experience. Before we transition to an updated search later this year, we have a beta version available for you to preview and test! Try PMC Beta Search and share your feedback … Continue reading PubMed Central’s Updated Full-Text Search Preview Now Available →

8 April 2025

Many people visit NCBI’s ClinVar site every day, multiple times a day. As the field of clinical genetics advances, more and more new visitors also come to ClinVar to research the clinical significance of genetic variants. Based on feedback from new and existing customers, we are improving the homepage to serve as a better introduction … Continue reading Coming Soon! Enhancements to ClinVar Homepage →

1 April 2025