Download the updated bacterial and archaeal reference genome collection! We built this collection of 22,082 genomes by selecting the “best” genome assembly for each species among the 440,000+ prokaryotic genomes in RefSeq.  What’s new?  28 species are represented in this collection for the first time  228 species are represented by a better assembly  Six species were removed … Continue reading An Updated Bacterial and Archaeal Reference Genome Collection is Available! →

2 September 2025

GenBank release 268.0 (8/18/2025) is now available on the NCBI FTP site. This release has 47.01 trillion bases and 5.90 billion records. The current release has:  258,320,620 traditional records containing 5,676,067,778,413 base pairs of sequence data 4,441,331,387 WGS records containing 40,390,433,406,298 base pairs of sequence data 1,010,159,820 bulk-oriented TSA records containing 864,483,775,194 base pairs of … Continue reading GenBank Release 268.0 is Available! →

26 August 2025

The volume of GenBank WGS, TSA, and TLS data sets is large and continues to grow rapidly. To help you identify and retrieve newly released data, we began providing symlinks and project list files in the Index of /genbank/daily-nc area approximately 12 years ago.  What’s new?  As the number of projects and files increases, the … Continue reading Upcoming Changes to GenBank Project Lists and Symlinks →

20 August 2025

Coming the week of September 7th   The new PubMed Central (PMC) Beta search will replace the current PMC search the week of September 7, 2025.   As previously announced, the National Library of Medicine (NLM) National Center for Biotechnology Information (NCBI) is working on an update to PMC full-text search functionality and user experience. To … Continue reading PubMed Central (PMC) Beta Search to Replace Current Search →

19 August 2025

ClinVar is pleased to announce that our improved representation of functional data is live on the website, in file submissions, and in downloadable XML files. The following documentation is provided to facilitate future submissions and downloads: Instructions for submitting functional data in our Excel submission templates Updated submission templates Updated XSD for downloadable XML files … Continue reading Now Live: Improved Representation of Functional Data in ClinVar! →

18 August 2025

Download release 18.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.  What’s new?  Release 18.0 contains:  18,057 HMMs maintained by NCBI  631 new HMMs since release 17.0  You … Continue reading Now Available! NCBI Hidden Markov Models (HMM) Release 18.0 →

14 August 2025

As previously announced, NCBI is improving the ClinVar homepage to serve as a better introduction to data and services within the resource. We are also enhancing your search experience in ClinVar!   Search enhancements  We are introducing a multiple box search interface where you can enter one or more terms. Each box will be labeled … Continue reading Coming Soon: ClinVar Search Enhancements →

22 July 2025

We are excited to announce redesigned NCBI Gene pages! The redesigned pages (available through NCBI Datasets) offer a modern, clean interface with an intuitive layout that makes browsing and downloading NCBI Gene data easier. The legacy Gene page will continue to be available during this transition period, and we will continue to communicate updates and … Continue reading Improved Gene Data Access with Redesigned NCBI Gene Pages →

14 July 2025

On Friday, July 25th, starting at 9:00 PM EDT, we’ll be performing essential maintenance on the NLM data center. This upgrade is critical to ensure the continued reliability and stability of our services. We anticipate this planned outage will last 24 hours or more. During this time, users may experience interrupted access or degraded performance … Continue reading NCBI Website Maintenance — Beginning July 25th →

8 July 2025

The National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) has made initial updates to several offerings to support NIH-funded researchers and institutions to comply with the 2024 NIH Public Access Policy, which went into effect July 1, 2025. NCBI will continue to make ongoing improvements over the coming months.   … Continue reading Updates to Offerings in Support of the 2024 NIH Public Access Policy →

2 July 2025