As previously announced, major changes are being made to enhance your GenBank submission experience. As of April 2026, you can submit to GenBank using our new simplified wizards in Submission Portal-GenBank.  What now?  Use Submission Portal-GenBank for all GenBank sequence submissions, except for sequence alignments  Use BankIt only if you are submitting aligned sequences for feature propagation  What’s next?  Later in 2026, all GenBank submissions, including … Continue reading BankIt Submitters: GenBank Submission Update →

26 May 2026

RefSeq release 235 is now available online and from the FTP site! You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings.     What’s included in this release?   As of May 11, 2026, this full release incorporates genomic, transcript, and protein data containing:    616,942,961 records   473,570,633 proteins   81,124,747 RNAs   Sequences from 180,620 organisms   New eukaryotic … Continue reading Now Available: RefSeq Release 235 →

21 May 2026

Sequence data from the recent Andes hantavirus outbreak are now available through NLM’s NCBI resources, NCBI Virus web interface and NCBI Datasets command-line tool. These data were submitted by the University Hospitals of Geneva.  Access through NCBI Virus  To find sequence records from 2026, search for “Orthohantavirus andesense” in NCBI Virus and apply the “Collection Date” filter. To get a quick overview … Continue reading New Data Available! Access Hantavirus Sequences at NCBI →

20 May 2026

Phasing out the Classic PRS  The National Library of Medicine (NLM) has completed modernization of the Protocol Registration and Results System (PRS) and the public website, ClinicalTrials.gov. The Modernized PRS is now the primary system for protocol registration and results submission, and we will continue to add new features based on your feedback!   Modernized PRS updates and new features  Highlights of updated and upcoming features:  … Continue reading Protocol Registration and Results System (PRS) Modernization →

19 May 2026

With New Evidence Source for Protein Naming  We are happy to announce the release of a new version of the stand-alone Prokaryotic Genome Annotation Pipeline (PGAP)!  What’s new?  Software updated to CheckM 1.2.5  Ongoing improved protein family model data used for annotation  Pfam release 38 is being used for structural and functional annotation  New evidence source: superfamilies  As with previous releases, curators at NCBI continue to expand the library of Protein … Continue reading New: May 2026 Release of Stand-Alone PGAP →

14 May 2026

In Support of the 2024 NIH Public Access Policy As part of continued enhancements to offerings to support NIH-funded researchers and institutions with compliance with the 2024 NIH Public Access Policy, the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) recently updated the NIH Manuscript Submission (NIHMS) system to facilitate review of … Continue reading Updates to the NIH Manuscript Submission (NIHMS) System →

5 May 2026

Announcing brownout periods when rsync will be disabled  As we previously announced, NCBI will discontinue support for the rsync protocol on June 1, 2026, as part of our ongoing effort to enhance security and efficiency. After June 1, attempts to connect to ftp.ncbi.nlm.gov using rsync will fail. To support this transition, we are announcing two temporary “brownout” periods. During these planned intervals, rsync access will be intentionally disabled … Continue reading Reminder! NCBI is Retiring rsync for FTP Downloads June 1, 2026 →

29 April 2026

GenBank release 271.0 (4/14/2026) is now available on the NCBI FTP site. This release has 53.90 trillion bases and 6.27 billion records.  The current release has:   261,460,182 traditional records containing 7,289,942,983,522 base pairs of sequence data 4,756,526,485 WGS records containing 45,628,511,953,497 base pairs of sequence data 1,058,643,373 bulk-oriented TSA records containing 898,651,493,967 base pairs of … Continue reading GenBank Release 271.0 is Available! →

27 April 2026

ClinVar is a free, public resource you can use to research the clinical significance of genetic variants. Many people visit ClinVar multiple times a day! We previously announced an upcoming enhanced search experience and new ClinVar homepage, and these improvements are now live.  What’s new?   Search enhancements  The new search interface provides different search boxes for the types of terms typically used to search ClinVar. These search … Continue reading ClinVar’s New Search Interface and Homepage are Here! →

23 April 2026

In September 2025, PubMed Central (PMC) launched a new full text search. Some previously available features were not included in the initial release. Now, PMC is rolling out additional search features based on your feedback.  What’s new?  Page navigation   PMC recently updated the search results interface to make it easier to navigate your results and customize how they appear.  Page navigation now appears at both the top and bottom of the … Continue reading PMC Continues to Improve New Search →

22 April 2026