Many people visit NCBI’s ClinVar site every day, multiple times a day. As the field of clinical genetics advances, more and more new visitors also come to ClinVar to research the clinical significance of genetic variants. Based on feedback from new and existing customers, we are improving the homepage to serve as a better introduction … Continue reading Coming Soon! Enhancements to ClinVar Homepage →

1 April 2025

RefSNP (rs) exceed 1.2 billion records  We are pleased to announce the release of the Database of Single Nucleotide Polymorphisms (dbSNP) Build 157, which has approximately 1.2 billion Reference SNP (rs) records across the human genome. This build includes updated datasets from 1000Genomes, TOPMed, gnomAD, NCBI ALFA release 3, and other studies that now incorporate … Continue reading dbSNP Build 157 Release →

18 March 2025

Check out RefSeq release 229, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of March 3, 2025, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 229 is Now Available! →

13 March 2025

GenBank release 265.0 (3/8/2025) is now available on the NCBI FTP site. This release has 41.96 trillion bases and 5.56 billion records. The current release has:  255,669,865 traditional records containing 5,415,448,651,743 base pairs of sequence data 4,152,691,448 WGS records containing 35,643,977,584,264 base pairs of sequence data 961,491,801 bulk-oriented TSA records containing 824,439,978,941 base pairs of … Continue reading GenBank Release 265.0 Now Available! →

11 March 2025

As previously announced, NCBI continues to make improvements to our Taxonomy resource. There have been recent updates to the International Code of Nomenclature of Prokaryotes (ICNP) and proposals by the International Committee on Taxonomy of Viruses (ICTV). As a result, NCBI Taxonomy has discontinued the use of rank “superkingdom” to classify organisms into Archaea, Bacteria, Eukaryota, … Continue reading New Ranks in NCBI Taxonomy: Domain & Realm →

27 February 2025

NLM’s NCBI is excited to introduce the Multiple Comparative Genome Viewer (MCGV), a new tool in active development that allows you to visualize an alignment of multiple eukaryotic genomes. While our existing Comparative Genome Viewer (CGV) allows you to compare pairs of eukaryotic assemblies, the new MCGV tool can help you analyze multiple assemblies in … Continue reading New! Introducing the Multiple Comparative Genome Viewer (MCGV) Beta Release →

16 January 2025

Download the updated bacterial and archaeal reference genome collection! We built this collection of 21,258 genomes by selecting the “best” genome assembly for each species among the 400,000+ prokaryotic genomes in RefSeq. What’s new? As previously announced, we updated our release process: There is now an incremental process. In addition to quarterly releases, there will … Continue reading An updated bacterial and archaeal reference genome collection is available! →

14 January 2025

The 2025 Nucleic Acids Research Database Issue features papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.  Database resources of the National Center for Biotechnology Information in 2025 PMCID: PMC11701734 NCBI provides online … Continue reading NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue →

13 January 2025

Check out RefSeq release 228, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of January 3, 2025, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 228 is Available! →

10 January 2025

The U.S. Centers for Disease Control and Prevention (CDC) has been monitoring the ongoing outbreak of the avian influenza A (H5N1) virus. This is widespread globally in wild birds, and has led to sporadic outbreaks in poultry, cows, several species of wild animals, and has been detected in exposed humans. The CDC recently sequenced the … Continue reading Access Avian Influenza A (H5N1) Virus Sequences from the Current Outbreak at NCBI →

8 January 2025