Latest release now available  Are you generating genomes for vertebrates, arthropods, or plants, and looking for a way to generate high-quality genome annotation? NCBI is working on a public version of the NCBI Eukaryotic Genome Annotation Pipeline (EGAPx), and the latest developmental release is now available for testing and feedback. What’s new?  Improved Gene Annotation: … Continue reading Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx →

20 November 2024

Check out RefSeq release 227, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 227 is Available! →

14 November 2024

We want your feedback!  As previously announced, NCBI is improving the way that functional data are submitted to ClinVar and how they are represented in the XML format and on the website. We have started enhancing support for functional data and would like your feedback!   What’s new?  We have updated the GitHub repository with:  Updated … Continue reading Update! Improving the Representation of Functional Data in ClinVar →

6 November 2024

250K+ new Hymenoptera orthologs added  NCBI is excited to announce the expansion of ortholog data for RefSeq arthropods. This update expands the breadth of arthropod orthology information, offering new insights into evolutionary biology, gene function, and shared pathways. Whether you’re studying insect genetics, developmental biology, or comparative genomics, the expanded ortholog data opens up new … Continue reading Expansion of Ortholog Data for RefSeq Arthropods →

30 October 2024

The next release (v1.4) of Matched Annotation from NCBI and EMBL-EBI (MANE) is here!  MANE is a collaborative dataset produced jointly by NCBI and EMBL-EBI that provides a representative transcript (MANE Select) for human protein-coding genes, to be used as universal standards for variant reporting and browser display. A second transcript, MANE Plus Clinical, is … Continue reading MANE v1.4 with MANE Select for Non-Coding Genes →

28 October 2024

GenBank release 263.0 (10/19/2024) is now available on the NCBI FTP site. This release has 36.50 trillion bases and 5.13 billion records. The current release has:  251,998,350 traditional records containing 4,250,942,573,681 base pairs of sequence data 3,745,772,758 WGS records containing 31,362,454,467,668 base pairs of sequence data 948,733,596 bulk-oriented TSA records containing 812,661,461,811 base pairs of … Continue reading GenBank Release 263.0 Now Available! →

24 October 2024

Improving Metadata Quality  Do you rely on high-quality metadata from NCBI’s BioSample database? BioSample is home to metadata associated with the biological source materials used to generate raw reads, sequences, and other data submitted to NCBI. We are improving our submission process to ensure we provide you with more complete and robust information.  Attention submitters!  … Continue reading Upcoming Changes to NCBI’s BioSample Database →

23 October 2024

New tutorials, queries, and discovery guides now available  NLM’s NCBI Bookshelf provides free access to more than 13,000 peer-reviewed books and documents in life science and health care using over a dozen formats including monographs, reviews, reference works, government publications, standards and guidelines, technical reports, and textbooks. In acknowledgement of Open Access Week, we are … Continue reading Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips →

22 October 2024

The next step in the modernization of PMC  As previously announced, NLM’s NCBI transitioned to an updated PubMed Central (PMC) website, representing the next step in ongoing efforts to modernize NLM’s products and services. As part of this update, the primary URL for the PMC website has changed from ncbi.nlm.nih.gov/pmc to pmc.ncbi.nlm.nih.gov. In addition, you’ll … Continue reading PubMed Central (PMC) Transitions to Updated Website →

21 October 2024

Are you interested in comparing gene families or exploring the evolution of domain architecture? Try our Conserved Domain Architecture Retrieval Tool (CDART) to retrieve sets of proteins that share the same or similar domain superfamily architecture with your query. We recently updated CDART so it’s faster and more streamlined with simplified navigation and result filtering.  … Continue reading CDART: Find Proteins with Similar Domain Architecture →

17 October 2024