NCBI is excited to introduce a fresh look and feel to the Database of Genotypes and Phenotypes (dbGaP). Our beta homepage is now available and will become the default later in 2025. We encourage you to try it out and let us know what you think! This represents the first step of our ongoing modernization … Continue reading Beta Now Live! New & Improved dbGaP Homepage Design →

2 June 2025

Download the updated bacterial and archaeal reference Genome collection! We built this collection of 21,794 genomes by selecting the “best” genome assembly for each species among the 400,000+ prokaryotic genomes in RefSeq, which is 536 more than was included in the January release. What’s new? As previously announced, we now have an incremental release process. You … Continue reading Now Available: Updated Bacterial and Archaeal Reference Genome Collection →

27 May 2025

Effective August 2025, ClusteredNR will become the protein BLAST default database  We are excited to announce that the default database for protein BLAST searches will soon be the NCBI ClusteredNR database! Introduced in 2022, ClusteredNR is a collection of protein sequence clusters built from the current default database, nr. The representative sequence for each cluster … Continue reading Faster, Better Results for Protein BLAST Searches →

22 May 2025

Starting April 28, 2025 In December 2024, we announced several key changes to virus classification in the NCBI Taxonomy database. These updates are part of our ongoing efforts to ensure viral taxonomy reflects the latest scientific understanding and aligns with international standards set by the International Committee on Taxonomy of Viruses (ICTV). We will begin … Continue reading NCBI Taxonomy Updates to Virus Classification →

25 April 2025

As previously announced, NLM’s NCBI is modernizing the PubMed Central (PMC) website. The next step is to update the PMC search functionality and user experience. Before we transition to an updated search later this year, we have a beta version available for you to preview and test! Try PMC Beta Search and share your feedback … Continue reading PubMed Central’s Updated Full-Text Search Preview Now Available →

8 April 2025

Many people visit NCBI’s ClinVar site every day, multiple times a day. As the field of clinical genetics advances, more and more new visitors also come to ClinVar to research the clinical significance of genetic variants. Based on feedback from new and existing customers, we are improving the homepage to serve as a better introduction … Continue reading Coming Soon! Enhancements to ClinVar Homepage →

1 April 2025

RefSNP (rs) exceed 1.2 billion records  We are pleased to announce the release of the Database of Single Nucleotide Polymorphisms (dbSNP) Build 157, which has approximately 1.2 billion Reference SNP (rs) records across the human genome. This build includes updated datasets from 1000Genomes, TOPMed, gnomAD, NCBI ALFA release 3, and other studies that now incorporate … Continue reading dbSNP Build 157 Release →

18 March 2025

Check out RefSeq release 229, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of March 3, 2025, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 229 is Now Available! →

13 March 2025

GenBank release 265.0 (3/8/2025) is now available on the NCBI FTP site. This release has 41.96 trillion bases and 5.56 billion records. The current release has:  255,669,865 traditional records containing 5,415,448,651,743 base pairs of sequence data 4,152,691,448 WGS records containing 35,643,977,584,264 base pairs of sequence data 961,491,801 bulk-oriented TSA records containing 824,439,978,941 base pairs of … Continue reading GenBank Release 265.0 Now Available! →

11 March 2025

As previously announced, NCBI continues to make improvements to our Taxonomy resource. There have been recent updates to the International Code of Nomenclature of Prokaryotes (ICNP) and proposals by the International Committee on Taxonomy of Viruses (ICTV). As a result, NCBI Taxonomy has discontinued the use of rank “superkingdom” to classify organisms into Archaea, Bacteria, Eukaryota, … Continue reading New Ranks in NCBI Taxonomy: Domain & Realm →

27 February 2025