Download release 17.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What’s New? Release 17.0 contains: 17,433 HMMs maintained by NCBI 386 new HMMs since release 16.0 You can search … Continue reading Now Available! NCBI Hidden Markov Models (HMM) Release 17.0 →

18 December 2024

To reflect changes to the International Code of Virus Classification and Nomenclature (ICVCN) made by the International Committee on Taxonomy of Viruses (ICTV), NCBI will add binomial species names to about 3000 viruses. These updates to NCBI Taxonomy are planned for spring 2025, but you can view the changes now in the ICTV’s Virus Metadata Resource.  We recognize that the former … Continue reading NCBI Taxonomy: Upcoming Changes to Viruses →

11 December 2024

Effective March 2025  Do you submit genomes to NCBI’s GenBank? Beginning March 2025, GenBank will no longer accept AGP files for genome submissions. Historically, AGP files were submitted along with contigs as necessary information for constructing assemblies. However, thanks to technology improvements, more and more whole genome shotgun (WGS) sequences submitted to NCBI are gapped … Continue reading AGP Files Will No Longer be Accepted for Genome Submissions →

4 December 2024

Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? Check out NCBI’s “I see in 3D” (iCn3D) – a free, web-based tool that allows you to explore the structure of a biomolecule at an atomistic level.  Features & Benefits  Interactively view 3D structure and … Continue reading Explore 3D Molecular Structures with iCn3D →

21 November 2024

Latest release now available  Are you generating genomes for vertebrates, arthropods, or plants, and looking for a way to generate high-quality genome annotation? NCBI is working on a public version of the NCBI Eukaryotic Genome Annotation Pipeline (EGAPx), and the latest developmental release is now available for testing and feedback. What’s new?  Improved Gene Annotation: … Continue reading Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx →

20 November 2024

Check out RefSeq release 227, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 227 is Available! →

14 November 2024

We want your feedback!  As previously announced, NCBI is improving the way that functional data are submitted to ClinVar and how they are represented in the XML format and on the website. We have started enhancing support for functional data and would like your feedback!   What’s new?  We have updated the GitHub repository with:  Updated … Continue reading Update! Improving the Representation of Functional Data in ClinVar →

6 November 2024

250K+ new Hymenoptera orthologs added  NCBI is excited to announce the expansion of ortholog data for RefSeq arthropods. This update expands the breadth of arthropod orthology information, offering new insights into evolutionary biology, gene function, and shared pathways. Whether you’re studying insect genetics, developmental biology, or comparative genomics, the expanded ortholog data opens up new … Continue reading Expansion of Ortholog Data for RefSeq Arthropods →

30 October 2024

The next release (v1.4) of Matched Annotation from NCBI and EMBL-EBI (MANE) is here!  MANE is a collaborative dataset produced jointly by NCBI and EMBL-EBI that provides a representative transcript (MANE Select) for human protein-coding genes, to be used as universal standards for variant reporting and browser display. A second transcript, MANE Plus Clinical, is … Continue reading MANE v1.4 with MANE Select for Non-Coding Genes →

28 October 2024

GenBank release 263.0 (10/19/2024) is now available on the NCBI FTP site. This release has 36.50 trillion bases and 5.13 billion records. The current release has:  251,998,350 traditional records containing 4,250,942,573,681 base pairs of sequence data 3,745,772,758 WGS records containing 31,362,454,467,668 base pairs of sequence data 948,733,596 bulk-oriented TSA records containing 812,661,461,811 base pairs of … Continue reading GenBank Release 263.0 Now Available! →

24 October 2024