Download release 15.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What’s New? Release 15.0 contains: 16,667 HMMs maintained by NCBI 279 new HMMs since release 14.0 Several … Continue reading NCBI Hidden Markov Models (HMM) Release 15.0 Now Available! →

23 April 2024

Removing contaminated sequences using NCBI quality assurance tools  Do you use BLAST to identify a sequence or the evolutionary scope of a gene? That can be challenging if contaminated and misclassified sequences are in the BLAST databases and show up in your search results. To address this problem, we now use the NCBI quality assurance … Continue reading Cleaner BLAST Databases for More Accurate Results →

22 April 2024

Check out the newly released Conserved Domain Database (CDD) version 3.21. Updated content is available on the CDD FTP site. What’s New? 1,174 new or updated NCBI-curated domains  Mirrors Pfam version 35 as well as new models from the NCBIfams collection and revised models from the Clusters of Orthologous Genes (COG) database Fine-grained classifications of the following domain families: … Continue reading Conserved Domain Database Version 3.21 Now Available! →

18 April 2024

New & improved NCBI Datasets Taxonomy pages and command-line service  NCBI Datasets is excited to introduce new features to our Taxonomy pages making it easier for you to access, browse, and download taxonomic information about organisms at any taxonomic level.   What’s new? Explore Taxonomy records with an updated look and feel   Access and download … Continue reading Browse Taxonomy Records with NCBI Datasets →

17 April 2024

In February and March, the NCBI Eukaryotic Genome Annotation Pipeline released forty-six new annotations in RefSeq! New Annotations Aedes albopictus (Asian tiger mosquito) Anolis carolinensis (green anole) Armigeres subalbatus (mosquito) Bacillus rossius redtenbacheri (walking stick) Bolinopsis microptera (comb jelly) Bombyx mori (domestic silkworm) Bubalus kerabau (carabao) Candoia aspera (snake) Cavia porcellus (domestic guinea pig)  Chroicocephalus ridibundus (black-headed … Continue reading New RefSeq Annotations Now Available! →

16 April 2024

We have made some exciting updates to the NIH Genetic Testing Registry (GTR) to give you a more modern, easier-to-navigate display of genetic test information. We encourage you to check out our latest improvements and let us know what you think.  What’s new? One page display (no more tabs)  At a glance section with a … Continue reading Easy Access to Genetic Test Information with the NIH Genetic Testing Registry (GTR) →

9 April 2024

Do you use NCBI’s MedGen? If so, then you probably know it’s NCBI’s one-stop-shop for genetic phenotype information. If you are a healthcare provider, genetic professional, researcher, or anyone who uses MedGen, we want to hear from you to help us make this resource better meet your needs!   We want to know:  How you currently … Continue reading MedGen Users, We Want Your Feedback! →

28 March 2024

Sequence Read Archive (SRA) data available via the Google Cloud Platform (GCP) are migrating from multi-region to single region us-east-1. This migration is projected to be complete by May 2024. To minimize the impact of this change, we recommend updating your workflow to access SRA data in us-east-1 region as soon as conveniently possible.  Please note … Continue reading Changes to SRA Data Access on the Google Cloud Platform (GCP) →

20 March 2024

Updated article display and journal list Since announcing the launch of a more modern PubMed Central (PMC) website in March 2022, NLM’s NCBI continues to make improvements based on your feedback. We invite you to preview the latest improvements planned for the PMC website. These improvements will become the default in October 2024 and include … Continue reading Preview Upcoming Improvements to PubMed Central (PMC) →

14 March 2024

An in-person training opportunity for science educators  Calling all high school, community college, and undergraduate science educators! NCBI is excited to host our first BioEd Summit on the National Institutes of Health (NIH) campus in Bethesda, MD, from August 5-9, 2024. Join us for a week-long, in-person event where you will collaborate with other educators … Continue reading Announcing NCBI’s First Ever BioEd Summit! →

13 March 2024