NLM’s NCBI is excited to introduce the Multiple Comparative Genome Viewer (MCGV), a new tool in active development that allows you to visualize an alignment of multiple eukaryotic genomes. While our existing Comparative Genome Viewer (CGV) allows you to compare pairs of eukaryotic assemblies, the new MCGV tool can help you analyze multiple assemblies in … Continue reading New! Introducing the Multiple Comparative Genome Viewer (MCGV) Beta Release →

16 January 2025

Download the updated bacterial and archaeal reference genome collection! We built this collection of 21,258 genomes by selecting the “best” genome assembly for each species among the 400,000+ prokaryotic genomes in RefSeq. What’s new? As previously announced, we updated our release process: There is now an incremental process. In addition to quarterly releases, there will … Continue reading An updated bacterial and archaeal reference genome collection is available! →

14 January 2025

The 2025 Nucleic Acids Research Database Issue features papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.  Database resources of the National Center for Biotechnology Information in 2025 PMCID: PMC11701734 NCBI provides online … Continue reading NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue →

13 January 2025

Check out RefSeq release 228, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of January 3, 2025, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 228 is Available! →

10 January 2025

The U.S. Centers for Disease Control and Prevention (CDC) has been monitoring the ongoing outbreak of the avian influenza A (H5N1) virus. This is widespread globally in wild birds, and has led to sporadic outbreaks in poultry, cows, several species of wild animals, and has been detected in exposed humans. The CDC recently sequenced the … Continue reading Access Avian Influenza A (H5N1) Virus Sequences from the Current Outbreak at NCBI →

8 January 2025

As we begin a new year, let’s look back at the top NCBI Insights Blog posts of 2024 based on number of views.   In case you missed any of these, check them out:  Learn more The NCBI Insights Blog is intended to help you better understand NCBI and our resources, explore issues of scientific interest … Continue reading Top of 2024: A Look at the NCBI Insights Blog  →

6 January 2025

GenBank release 264.0 (12/19/2024) is now available on the NCBI FTP site. This release has 38.97 trillion bases and 5.36 billion records. The current release has:  254,365,075 traditional records containing 5,085,904,976,338 base pairs of sequence data 3,957,195,833 WGS records containing 32,983,029,087,303 base pairs of sequence data 957,403,887 bulk-oriented TSA records containing 820,128,973,511 base pairs of … Continue reading GenBank Release 264.0 Now Available! →

23 December 2024

Download release 17.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What’s New? Release 17.0 contains: 17,433 HMMs maintained by NCBI 386 new HMMs since release 16.0 You can search … Continue reading Now Available! NCBI Hidden Markov Models (HMM) Release 17.0 →

18 December 2024

To reflect changes to the International Code of Virus Classification and Nomenclature (ICVCN) made by the International Committee on Taxonomy of Viruses (ICTV), NCBI will add binomial species names to about 3000 viruses. These updates to NCBI Taxonomy are planned for spring 2025, but you can view the changes now in the ICTV’s Virus Metadata Resource.  We recognize that the former … Continue reading NCBI Taxonomy: Upcoming Changes to Viruses →

11 December 2024

Effective March 2025  Do you submit genomes to NCBI’s GenBank? Beginning March 2025, GenBank will no longer accept AGP files for genome submissions. Historically, AGP files were submitted along with contigs as necessary information for constructing assemblies. However, thanks to technology improvements, more and more whole genome shotgun (WGS) sequences submitted to NCBI are gapped … Continue reading AGP Files Will No Longer be Accepted for Genome Submissions →

4 December 2024